MassCheck® Immunosuppressants Whole Blood Controls, lyophilised.
For MassTox® Immunosuppressants in Whole Blood.
0081 Four-Level, 4 x 2 x 2 ml
0082 Level I, 5 x 2 ml
0083 Level II, 5 x 2 ml
0084 Level III, 5 x 2 ml
0085 Level IV, 5 x 2 ml
0089 Blank Control, 5 x 2 ml
These lyophilised quality controls from Chromsystems are based on human whole blood and should be used according to the instruction manual. They are designed to monitor the accuracy and precision of analytical procedures in clinical diagnostics for the quantitative determination of cyclosporin A, rapamycin, tacrolimus and everolimus in whole blood. While following the instructions the controls should be handled and measured in the same manner as a patient specimen.
Technical Data
Method of Analysis
LC-MS/MS
Concentrations
Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.
| | Level I | Level II | Level III | Level IV |
| Substance | Method | Unit | Value | Range | Value | Range | Value | Range | Value | Range |
| Cyclosporin A | HPLC-UV | g/l | 96 | 77-115 | 242 | 193-290 | 476 | 381-572 | 1899 | 1519-2278 |
| | Dade-Behring EMIT | g/l | 101 | 81-121 | 247 | 198-296 | 467 | 374-560 | 2051 | 1641-2461 |
| | Abbott TDx | g/l | 110 | 83-138 | 274 | 198-296 | 528 | 396-659 | 1833 | 1375-2291 |
| Rapamycin (Sirolimus) | LC-MS/MS | g/l | 3.7 | 2.6-4.8 | 9.1 | 7.3-10.9 | 18.0 | 14.4-21.6 | 39.2 | 31.4-47.0 |
| Tacrolimus (FK 506) | Abbott IMx | g/l | 6.4 | 5.1-7.7 | 12.2 | 9.8-14.6 | 23.7 | 19.0-28.4 | 44.6 | 35.7-53.5 |
| | LC-MS/MS | g/l | 3.4 | 2.7-4.1 | 8.2 | 6.6-9.8 | 18.1 | 14.5-21.7 | 36.0 | 28.8-43.2 |
| Everolimus | LC-MS/MS | g/l | 2.5 | 1.6-3.3 | 4.4 | 2.9-6.0 | 8.9 | 5.7-11.9 | 30.1 | 21.1-39.1 |
Reconstitution
Carefully remove the metal seal and rubber stopper from the vials. Add exactly 2.0 ml of distilled water into each vial. Return the stopper and incubate for 10 to 15 minutes at room temperature. Swirl the vials to dissolve the contents until homogeneity.
Storage conditions
Stored below -18 °C and unopened, the lyophilised controls are stable until the expiry date specified on the vial labels. The reconstituted controls can be stored up to 1 week light protected and tightly capped at +2 to +8 C. If the controls cannot be used within this period, they should be aliquoted and stored frozen below -18 °C (up to 9 months). For more details about storage conditions please check your instruction manual.
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